Hal dariiqo oo unugyada kansarku ay uga dhuuntaan habka difaaca jidhka waa iyaga oo samaysta xannibaad dusha dhuuban oo loo yaqaan glycocalyx. Daraasaddan cusub, cilmi-baarayaashu waxay baareen sifooyinka walxaha ee xannibaaddan oo leh xallin aan hore loo arag, oo daaha ka qaaday macluumaad caawin kara hagaajinta difaaca unugyada kansarka unugyada hadda.
Unugyada kansarku waxay inta badan sameeyaan glycocalyx oo leh heerar sare oo ah dheecaannada dusha sare ee unugyada, kuwaas oo loo maleynayo inay ka caawiyaan ilaalinta unugyada kansarka weerarka unugyada difaaca. Si kastaba ha ahaatee, fahamka jireed ee caqabadan ayaa weli xaddidan, gaar ahaan marka la eego immunotherapy-ga unugyada kansarka, taas oo ku lug leh ka saarista unugyada difaaca bukaanka, wax ka beddelka iyaga si ay u raadiyaan oo u baabi'iyaan kansarka, ka dibna dib ugu celisa bukaanka.
"Waxaan ogaanay in isbeddelada dhumucda xannibaadda ee yar yar ee 10 nanometer ay saameeyaan dhaqdhaqaaqa antitumor ee unugyadeena difaaca ama unugyada difaaca jirka," ayuu yiri Sangwu Park, arday ka qalin jabiyay shaybaarka Matthew Paszek ee Jaamacadda Cornell ee ISAB, New York. "Waxaan u isticmaalnay macluumaadkan si aan u naqshadeyno unugyada difaaca ee ka gudbi kara glycocalyx, waxaana rajeyneynaa in habkan loo isticmaali karo si loo hagaajiyo difaaca unugyada casriga ah." Bayoloji.
"Shaybaarkayagu waxa uu la yimid istaraatijiyad awood leh oo loo yaqaan 'scanning angle internation microscopy' (SAIM) si loo cabbiro glycocalyx nanosized ee unugyada kansarka," ayuu yiri Park. "Farsamada sawir-qaadista ayaa noo ogolaatay inaan fahamno xiriirka qaabdhismeedka ee mucins-ku-xiran kansarka leh sifooyinka biophysical ee glycocalyx."
Cilmi-baadhayaashu waxay sameeyeen qaabka gacanta si ay si sax ah u xakameeyaan muujinta xuubka unugyada unugyada si ay ugu ekaadaan glycocalyx ee unugyada kansarka. Kadibna waxay ku biiriyeen SAIM habka hidde-sidaha si ay u baaraan sida cufnaanta dusha sare, glycosylation, iyo isku-xidhka isku-xidhka mucins-ku-xiran ee kansarka ay u saameeyaan dhumucda nanoscale barrier. Waxay kaloo falanqeeyeen sida dhumucda glycocalyx ay u saamayso iska caabinta unugyada inay weeraraan unugyada difaaca.
Daraasadu waxay muujinaysaa in dhumucda unugyada kansarka ee glycocalyx ay tahay mid ka mid ah halbeegyada ugu muhiimsan ee lagu go'aamiyo baxsiga unugyada difaaca, iyo in unugyada difaaca jirka ay si fiican u shaqeeyaan haddii glycocalyx uu khafiif yahay.
Iyada oo ku saleysan aqoontan, cilmi-baarayaashu waxay naqshadeeyeen unugyada difaaca jirka oo leh enzymes gaar ah oo korkooda ah kuwaas oo u oggolaanaya inay ku dhejiyaan oo ay la falgalaan glycocalyx. Tijaabooyin lagu sameeyay heerka gacanta ayaa muujiyay in unugyadan difaaca ay awoodaan inay ka gudbaan hubka glycocalyx ee unugyada kansarka.
Cilmi-baarayaashu waxay markaa qorsheynayaan inay go'aamiyaan in natiijooyinkan lagu soo celin karo shaybaarka iyo ugu dambeyntii tijaabooyinka bukaan-socodka.
Sangwoo Park waxay soo bandhigi doontaa daraasaddan (kooban) inta lagu jiro fadhiga "Glycosylation Regulation in Spotlight" Axadda, Maarso 26, 2-3 pm PT, Seattle Convention Center, qolka 608. La xidhiidh kooxda warbaahinta si aad u hesho macluumaad dheeraad ah ama si bilaash ah ugu gudbi shirka.
Nancy D. Lamontagne waa qoraa saynis iyo tafatire ka ah Qorista Sayniska Hal-abuurka ee Chapel Hill, North Carolina.
Geli ciwaanka iimaylkaaga waxaanu kuu soo diri doonaa maqaaladii ugu dambeeyay, waraysiyo iyo wiig ka badan
Daraasad cusub oo Pennsylvania ah ayaa iftiiminaysa sida borotiinnada khaaska ah u furaan dhismooyinka adag ee walxaha hidde-sidaha si loo isticmaalo.
May waa bisha wacyigelinta cudurada ee Huntington, haddaba aan si qoto dheer u eegno waxa uu yahay iyo halka aan ku daweyn karno.
Cilmi-baarayaasha gobolka Penn waxay ogaadeen in ligand reseptor ligand ay ku xiran tahay arrin qoraal ah oo kor u qaadeysa caafimaadka mindhicirka.
Cilmi-baadhayaashu waxay muujinayaan in walxaha fosfolipid ee cuntada reer galbeedka ay gacan ka geystaan kordhinta heerarka sunta bakteeriyada xiidmaha, caabuqa nidaamka, iyo samaynta huurada atherosclerotic.
Mudnaanta tarjumaada "barcode". Burburinta borotiinka cusub ee cudurada maskaxda. Unugyada muhiimka ah ee catabolism dhibicda lipid. Akhri maqaalladii ugu dambeeyay ee mowduucyadan.
Waqtiga boostada: Meey-22-2023